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palmitoylation 2

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acute myeloid leukemia 1

acyl-CoA synthetase long chain family member 5 1

combination target therapy 1

mutant GNAQ/11 1

uveal melanoma 1

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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: GNAQ/11 relies on palmitoylation for membrane association and signal transduction.Despite the palmitoylation of GNAQ/11 was discovered long before, its implication in UM remains unclearHere, results of palmitoylation-targeted mutagenesis and chemical interference approaches revealed thatthe loss of GNAQ/11 palmitoylation substantially affected tumor cell proliferation and survival in UMPalmitoylation inhibition through the mutation of palmitoylation sites suppressed GNAQ/11Q209L

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling by palmitoylation

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: of ACSL5 suppressed the activation of the Wnt/β-catenin pathway by suppressing the palmitoylation

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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Title Author Date Type Operation

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Journal Article

a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling by palmitoylation

Journal Article